Biotechnology tools — or the techniques, technology and instruments used to study, modify or create biological systems — have the potential to solve issues in human health, sustainability and the environment. Chemical & Materials Engineering Assistant Professor Maryam Raeeszadeh-Sarmazdeh is working to develop novel biotechnology tools, drawing upon her expertise in biomolecular engineering and synthetic biology. Here, she shares a few thoughts about her work.
Q: What are you currently working on?
A: I lead a research group focused on biomolecular engineering. We develop cutting-edge biotechnology tools. My work primarily revolves around protein engineering and design, with applications in cancer treatment, neurodegenerative diseases and sustainable biocatalysis. Proteins are key molecules that regulate many vital cell functions. By understanding how they work and interact, we gain powerful insights into developing new biotechnology solutions.
One exciting project I’m working on involves metalloproteinases — enzymes that remodel the extracellular matrix and interact with various cell signaling molecules. I’m leading a team to engineer selective inhibitors for these enzymes that can be used as therapeutics. These inhibitors could help regulate harmful metalloproteinase activity in diseases while preserving their beneficial functions in the body — something not possible with natural proteins or other chemicals. This is where protein engineering and new synthetic biology technologies come in, opening up incredible possibilities.
Q: What inspired you to pursue this line of research?
A: My journey into biomolecular engineering and synthetic biology began during my doctoral studies. During that time, I explored protein engineering using yeast surface display and directed evolution. I was captivated by the idea of engineering and designing proteins to perform specific functions. The potential applications of these technologies addressed real-world challenges, and this struck me as incredibly exciting.
This inspiration led me to pursue postdoctoral research at the University of Delaware, where I worked on enzyme and metabolic pathway engineering. Later, at the Mayo Clinic, I focused on engineering protein-based therapeutics. These experiences solidified my passion for the field and helps me see its potential to improve both human health and the environment.
Q: What potential impact can this work have on society?
A: The research I’m involved in has the potential to change lives by providing innovative solutions to some of society’s most pressing challenges. In healthcare, engineered proteins and enzymes could lead to more targeted and effective therapies for diseases like cancer, neurodegenerative disorders and cardiovascular issues. For example, the selective metalloproteinase inhibitors we’re developing could offer new treatment options for conditions like Alzheimer’s disease and cancer, where current therapies are limited.
The part of my work that excites me the most is training the next generation of biomolecular engineers. I’m proud to teach an interdisciplinary class, Biomolecular Engineering (CHE 426-626), where I introduce students to the cutting-edge technologies that are shaping the future.
In my lab, I work with a great group of students — from high schoolers to postdocs — across fields like biology, biochemistry, biomedical engineering and chemical engineering. Mentoring these students is both challenging and rewarding. There’s nothing more inspiring than watching them grow, working together to solve complex problems. I truly enjoy being part of their journeys into the world of bioengineering.
